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Preheat your oven to 200°C (400°F).
Trim and halve the Brussels sprouts. Place them in a large mixing bowl.
Cut the chicken breasts into large chunks or leave whole as preferred. Add to the bowl with Brussels sprouts.
Drizzle 2 tablespoons of olive oil over the chicken and Brussels sprouts. Add 1 teaspoon dried oregano, 1 teaspoon garlic powder, 1/2 teaspoon black pepper, and 1/2 teaspoon salt. Zest the lemon and add the zest to the bowl. Toss everything together until well coated.
Spread the chicken and Brussels sprouts evenly on a large baking sheet lined with parchment paper.
Slice the lemon in half. Squeeze the juice of half the lemon over the chicken and sprouts. Reserve the other half for serving.
Bake in the preheated oven for 25-30 minutes, or until the chicken is cooked through and the Brussels sprouts are golden and tender.
While the chicken bakes, prepare the tzatziki: Grate the cucumber and squeeze out excess moisture. In a bowl, combine 200g Greek yogurt, grated cucumber, 1 minced garlic clove, 1 tablespoon chopped fresh dill, juice from the remaining half lemon, and 1/2 teaspoon salt. Mix well and refrigerate until ready to serve.
Once the chicken and Brussels sprouts are done, remove from the oven. Serve hot with a generous dollop of tzatziki on the side. Enjoy your Oven-Baked Mediterranean Chicken with Brussels Sprouts and Tzatziki!