1In a large bowl, combine the buttermilk and chicken drumsticks. Cover and refrigerate for at least 1 hour, or overnight for best results.
In another bowl, mix together the flour, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper.
Remove the chicken from the buttermilk, allowing any excess to drip off. Dredge each piece in the flour mixture, ensuring an even coating.
In a large skillet or deep fryer, heat the vegetable oil to 350°F (175°C).
Carefully place the coated chicken drumsticks into the hot oil. Fry in batches if necessary to avoid overcrowding.
Fry the chicken for about 12-15 minutes, turning occasionally, until golden brown and cooked through. The internal temperature should reach 165°F (74°C).
Remove the chicken from the oil and place on a paper towel-lined plate to drain excess oil.
Serve hot and enjoy your Classic Southern Fried Chicken!