1In a large bowl, combine the buttermilk, paprika, garlic powder, onion powder, salt, black pepper, and cayenne pepper.
Add the chicken tenders to the bowl and ensure they are fully coated with the buttermilk mixture. Cover and refrigerate for at least 1 hour.
In a separate bowl, add the all-purpose flour.
Heat the vegetable oil in a large skillet over medium-high heat until it reaches 350°F (175°C).
Remove the chicken tenders from the buttermilk mixture, allowing any excess to drip off, and dredge them in the flour, ensuring they are fully coated.
Carefully place the coated chicken tenders into the hot oil, frying in batches if necessary to avoid overcrowding the skillet.
Fry the chicken tenders for about 6-8 minutes, turning occasionally, until they are golden brown and cooked through.
Remove the chicken tenders from the oil and place them on a paper towel-lined plate to drain any excess oil.
Serve the Southern Fried Chicken Tenders hot with your favorite dipping sauce.